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Please use this identifier to cite or link to this item: http://hdl.handle.net/10928/461

Title: A New Testing Procedure for the Probability of Rare Events
Authors: YOSHIDA, Kiyotaka
IWASAKI, Manabu
Keywords: beta-binomial distribution
negative binomial distribution
power function
rare event.
Issue Date: 1-Dec-2013
Publisher: 成蹊大学理工学部
Abstract: We consider a testing procedure for the occurrence probability of rare events such as a severe adverse drug reaction observed after the release of a drug to market. Occurrence probabilities in two periods or populations Ω_0 and Ω_1 are compared. Under the condition that k events were observed among n patients for one population Ω_0, we test whether the occurrence probability for the second period or population Ω_1 is the same as that in Ω_0. We derive the null distribution and the non-null distribution of the test statistic both in exact and approximate forms, and make numerical assessment of the accuracy of the approximation. Further, the power function is also derived and the power of the test will be evaluated using the power function.
URI: http://hdl.handle.net/10928/461
Appears in Collections:第50巻第2号

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