有機ビスマス化合物の生物活性と作用機序

Abstract

Metals and metal compounds have been used in medicine for several thousand years. Bismuth is an unusual element in terms of its low toxicity and non-carcinogenic nature despite its heavy metal status. Traditionally, inorganic bismuth compounds have been widely used in medicine and veterinary practice. In particular, bismuth compounds have been used in the treatment of various microbial infections. We previously reported that bismuth compounds have anti-proliferative effects on various cancer cell lines. Bi-chlorodibenzo [c,f][1,5] thiabismocine (compound 3), one of these bismuth compounds, induced apoptotic and necrotic cell death via mitochondrial dysfunction in leukemic cells. Compound 3 also inhibited tubulin polymerization in HeLa cells. Several reports have shown that some bismuth compounds have multiple activities against cancer cells. This review summarizes reports of the activity of bismuth compounds in cancer cell lines.