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09:理工学研究報告 >
第54巻第2号 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10928/977

Title: 有機ビスマス化合物の生物活性と作用機序
Other Titles: Bioactivity and Mechanisms of Action of Organobismuth Compounds
Authors: 井内, 勝哉
IUCHI, Katsuya
Keywords: organobismuth
cell death
anticancer
Issue Date: Dec-2017
Publisher: 成蹊大学理工学部
Abstract: Metals and metal compounds have been used in medicine for several thousand years. Bismuth is an unusual element in terms of its low toxicity and non-carcinogenic nature despite its heavy metal status. Traditionally, inorganic bismuth compounds have been widely used in medicine and veterinary practice. In particular, bismuth compounds have been used in the treatment of various microbial infections. We previously reported that bismuth compounds have anti-proliferative effects on various cancer cell lines. Bi-chlorodibenzo [c,f][1,5] thiabismocine (compound 3), one of these bismuth compounds, induced apoptotic and necrotic cell death via mitochondrial dysfunction in leukemic cells. Compound 3 also inhibited tubulin polymerization in HeLa cells. Several reports have shown that some bismuth compounds have multiple activities against cancer cells. This review summarizes reports of the activity of bismuth compounds in cancer cell lines.
URI: http://hdl.handle.net/10928/977
Appears in Collections:第54巻第2号

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